Mitochondrial haplogroups H and J: risk and protective factors for ischemic cardiomyopathy.

ABSTRACT:

Background

Since mitochondria are the principal source of reactive oxygen species (ROS), these organelles may play an important role in ischemic cardiomyopathy (IC) development. The mitochondrial genome may influence this disease. The aim of the present study was to test the relationship between IC development and the impact of single nucleotide polymorphisms (SNPs) in mitochondrial DNA (mtDNA) defining the mitochondrial haplogroups in a population study.

Methodology and principal findings

Ten major European haplogroups were identified by using the single base extension technique and by polymerase chain reaction-restriction fragment length polymorphism. Frequencies and Odds Ratios for the association between IC patients (n = 358) and healthy controls (n = 423) were calculate

SUBMITTER: Fernandez-Caggiano M 

PROVIDER: S-EPMC3429437 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature