MiRNA regulation of gene expression: a predictive bioinformatics analysis in the postnatally developing monkey hippocampus.

ABSTRACT: Regulation of gene expression in the postnatally developing hippocampus might contribute to the emergence of selective memory function. However, the mechanisms that underlie the co-regulation of expression of hundreds of genes in different cell types at specific ages in distinct hippocampal regions have yet to be elucidated. By performing genome-wide microarray analyses of gene expression in distinct regions of the monkey hippocampal formation during early postnatal development, we identified one particular group of genes exhibiting a down-regulation of expression, between birth and six months of age in CA1 and after one year of age in CA3, to reach expression levels observed at 6-12 years of age. Bioinformatics analyses using NCBI, miRBase, TargetScan, microRNA.org and Affymetrix tools id

SUBMITTER: Favre G 

PROVIDER: S-EPMC3429458 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature