Abnormal initiation and conduction of slow-wave activity in gastroparesis, defined by high-resolution electrical mapping.

ABSTRACT:

Background & aims

Interstitial cells of Cajal (ICC) generate slow waves. Disrupted ICC networks and gastric dysrhythmias are each associated with gastroparesis. However, there are no data on the initiation and propagation of slow waves in gastroparesis because research tools have lacked spatial resolution. We applied high-resolution electrical mapping to quantify and classify gastroparesis slow-wave abnormalities in spatiotemporal detail.

Methods

Serosal high-resolution mapping was performed using flexible arrays (256 electrodes; 36 cm(2)) at stimulator implantation in 12 patients with diabetic or idiopathic gastroparesis. Data were analyzed by isochronal mapping, velocity and amplitude field mapping, and propagation animation. ICC numbers were determined from gastric biopsy

SUBMITTER: O'Grady G 

PROVIDER: S-EPMC3429650 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature