OPOSSUM-3: advanced analysis of regulatory motif over-representation across genes or ChIP-Seq datasets.

ABSTRACT: oPOSSUM-3 is a web-accessible software system for identification of over-represented transcription factor binding sites (TFBS) and TFBS families in either DNA sequences of co-expressed genes or sequences generated from high-throughput methods, such as ChIP-Seq. Validation of the system with known sets of co-regulated genes and published ChIP-Seq data demonstrates the capacity for oPOSSUM-3 to identify mediating transcription factors (TF) for co-regulated genes or co-recovered sequences. oPOSSUM-3 is available at http://opossum.cisreg.ca.

SUBMITTER: Kwon AT 

PROVIDER: S-EPMC3429929 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature