The effects of moderate-dose steroid therapy in sepsis: A placebo-controlled, randomized study.

ABSTRACT:

Background

Despite the new developments in sepsis treatment, mortality rate is still high. In this study, we aimed to investigate endocrinologic changes and the effects of moderate dosage steroid treatment in patients with sepsis.

Methods

Fifty-five patients were included in the study. Basal hormonal evaluation and adrenocorticotropin hormone (ACTH) stimulation test were performed within 24 h in all patients. Both groups received standard treatment for sepsis. However, one group (steroid group) was also given intravenous prednisolone (20 mg/day). All-cause mortality was assessed during the first 28 days.

Results

Analysis of the findings revealed a 59.3% mortality rate in steroid group compared with a 53.6% mortality rate in placebo group (p = 0.787). Acute Physiology

SUBMITTER: Yildiz O 

PROVIDER: S-EPMC3430057 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature