An injectable adipose matrix for soft-tissue reconstruction.

ABSTRACT:

Background

Soft-tissue repair is currently limited by the availability of autologous tissue sources and the absence of an ideal soft-tissue replacement comparable to native adipose tissue. Extracellular matrix-based biomaterials have demonstrated great potential as instructive scaffolds for regenerative medicine, mechanically and biochemically defined by the tissue of origin. As such, the distinctive high lipid content of adipose tissue requires unique processing conditions to generate a biocompatible scaffold for soft-tissue repair.

Methods

Human adipose tissue was decellularized to obtain a matrix devoid of lipids and cells while preserving extracellular matrix architecture and bioactivity. To control degradation and volume persistence, the scaffold was cross-linked using

SUBMITTER: Wu I 

PROVIDER: S-EPMC3430131 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature