Gene-expression changes caused by inbreeding protect against inbreeding depression in Drosophila.

ABSTRACT: We present a transcriptomic analysis aimed at investigating whether the changes in gene expression that occur under inbreeding generally reduce or enhance inbreeding depression. Discerning between these two alternatives can be addressed only when both changes in expression due to inbreeding and to inbreeding depression are estimated simultaneously. We used Affymetrix 2.0 arrays to study the changes in gene expression associated with both inbreeding and inbreeding depression for fitness in four sets of inbred sublines of Drosophila melanogaster. We found that for most genes showing changes in expression associated with inbreeding, the least depressed sublines were those showing the largest departures in expression from that of the outbred control. This suggests a pattern consistent with a p

SUBMITTER: Garcia C 

PROVIDER: S-EPMC3430533 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature