Immunophenotyping invasive breast cancer: paving the road for molecular imaging.

ABSTRACT:

Background

Mammographic population screening in The Netherlands has increased the number of breast cancer patients with small and non-palpable breast tumors. Nevertheless, mammography is not ultimately sensitive and specific for distinct subtypes. Molecular imaging with targeted tracers might increase specificity and sensitivity of detection. Because development of new tracers is labor-intensive and costly, we searched for the smallest panel of tumor membrane markers that would allow detection of the wide spectrum of invasive breast cancers.

Methods

Tissue microarrays containing 483 invasive breast cancers were stained by immunohistochemistry for a selected set of membrane proteins known to be expressed in breast cancer.

Results

The combination of highly tumor-specifi

SUBMITTER: Vermeulen JF 

PROVIDER: S-EPMC3430576 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature