Genotoxicity and molecular response of silver nanoparticle (NP)-based hydrogel.

ABSTRACT:

Background

Since silver-nanoparticles (NPs) possess an antibacterial activity, they were commonly used in medical products and devices, food storage materials, cosmetics, various health care products, and industrial products. Various silver-NP based medical devices are available for clinical uses, such as silver-NP based dressing and silver-NP based hydrogel (silver-NP-hydrogel) for medical applications. Although the previous data have suggested silver-NPs induced toxicity in vivo and in vitro, there is lack information about the mechanisms of biological response and potential toxicity of silver-NP-hydrogel.

Methods

In this study, the genotoxicity of silver-NP-hydrogel was assayed using cytokinesis-block micronucleus (CBMN). The molecular response was studied using DNA micro

SUBMITTER: Xu L 

PROVIDER: S-EPMC3430588 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature