Influence of CYP2C9 and VKORC1 on patient response to warfarin: a systematic review and meta-analysis.

ABSTRACT:

Background

Warfarin is a highly effective anticoagulant however its effectiveness relies on maintaining INR in therapeutic range. Finding the correct dose is difficult due to large inter-individual variability. Two genes, CYP2C9 and VKORC1, have been associated with this variability, leading to genotype-guided dosing tables in warfarin labeling. Nonetheless, it remains unclear how genotypic information should be used in practice. Navigating the literature to determine how genotype will influence warfarin response in a particular patient is difficult, due to significant variation in patient ethnicity, outcomes investigated, study design, and methodological rigor. Our systematic review was conducted to enable fair and accurate interpretation of which variants affect which outcomes, i

SUBMITTER: Jorgensen AL 

PROVIDER: S-EPMC3430615 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature