Metabolic profile of PML lesions in patients with and without IRIS: an observational study.

ABSTRACT:

Objective

To characterize progressive multifocal leukoencephalopathy (PML) lesions by contrast-enhanced MRI and evaluate their metabolism using proton magnetic resonance spectroscopy ((1)H- MRS) in the setting of immune reconstitution inflammatory syndrome (IRIS).

Methods

A total of 42 patients with PML underwent a clinical evaluation as well as brain MRI and (1)H-MRS at baseline and 3, 6, and 12 months later. The presence of IRIS was determined based on clinical and laboratory criteria. Ratios of N-acetylaspartate (NAA), choline (Cho), myo-inositol (mI), and lipid/lactate (Lip1 and Lip2) to creatine (Cr) were measured and correlated with the presence of contrast enhancement (CE) in PML lesions.

Results

IRIS occurred in 16 of 28 (57.1%) PML survivors (PML-S) and 1 of

SUBMITTER: Gheuens S 

PROVIDER: S-EPMC3430711 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature