Coexistence of different circulating anti-podocyte antibodies in membranous nephropathy.

ABSTRACT:

Background and objectives

The discovery of different podocyte autoantibodies in membranous nephropathy (MN) raises questions about their pathogenetic and clinical meaning. This study sought to define antibody isotypes and correlations; to compare levels in MN, other glomerulonephritides, and controls; and to determine their association with clinical outcomes.

Design, setting, participants, & measurements

Serum IgG(1), IgG(3), and IgG(4) against aldose reductase (AR), SOD2, and α-enolase (αENO) were measured at diagnosis in 186 consecutive MN patients, in 96 proteinuric controls (36 with FSGS, and 60 with IgA nephropathy), and in 92 healthy people recruited in four Italian nephrology units. Anti-phospholipase A2 receptor (PLA2r) and anti-neutral endopeptidase (NEP) IgG(4) wer

SUBMITTER: Murtas C 

PROVIDER: S-EPMC3430946 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature