25-Hydroxyvitamin D response to cholecalciferol supplementation in hemodialysis.

ABSTRACT:

Background and objectives

Recent understanding of extrarenal production of calcitriol has led to the exploration of native vitamin D treatment in dialysis patients. This paper reports the pharmacokinetics of 25-hydroxyvitamin D response to 10,333 IU cholecalciferol given weekly in subjects on chronic dialysis.

Design, setting, participants, & measurements

This randomized, double-blind, placebo-controlled trial of 15 weeks of oral cholecalciferol in subjects with stage 5 CKD requiring maintenance hemodialysis was conducted from November of 2007 to March of 2010. The time course of serum 25-hydroxyvitamin D was measured over the course of treatment. Additionally, blood was drawn at baseline and last visit for calcium, phosphorus, calcitriol, and parathyroid hormone levels.

SUBMITTER: Armas LA 

PROVIDER: S-EPMC3430950 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature