Microbial transformation from normal oral microbiota to acute endodontic infections.

ABSTRACT:

Background

Endodontic infections are a leading cause of oro-facial pain and tooth loss in western countries, and may lead to severe life-threatening infections. These infections are polymicrobial with high bacterial diversity. Understanding the spatial transition of microbiota from normal oral cavities through the infected root canal to the acute periapical abscess can improve our knowledge of the pathogenesis of endodontic infections and lead to more effective treatment. We obtained samples from the oral cavity, infected root canal and periapical abscess of 8 patients (5 with localized and 3 with systemic infections). Microbial populations in these samples were analyzed using next-generation sequencing of 16S rRNA amplicons. Bioinformatics tools and statistical tests with rigorous

SUBMITTER: Hsiao WW 

PROVIDER: S-EPMC3431219 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature