Linkage disequilibrium and inbreeding estimation in Spanish Churra sheep.

ABSTRACT:

Background

Genomic technologies, such as high-throughput genotyping based on SNP arrays, have great potential to decipher the genetic architecture of complex traits and provide background information concerning genome structure in domestic animals, including the extent of linkage disequilibrium (LD) and haplotype blocks. The objective of this study was to estimate LD, the population evolution (past effective population size) and the level of inbreeding in Spanish Churra sheep.

Results

A total of 43,784 SNPs distributed in the ovine autosomal genome was analyzed in 1,681 Churra ewes. LD was assessed by measuring r2 between all pairs of loci. For SNPs up to 10  kb apart, the average r2 was 0.329; for SNPs separated by 200-500  kb the average r2 was 0.061. When SNPs are separat

SUBMITTER: Garcia-Gamez E 

PROVIDER: S-EPMC3431250 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature