A systems biology approach reveals common metastatic pathways in osteosarcoma.

ABSTRACT:

Background

Osteosarcoma (OS) is the most common malignant bone tumor in children and adolescents. The survival rate of patients with metastatic disease remains very dismal. Nevertheless, metastasis is a complex process and a single-level analysis is not likely to identify its key biological determinants. In this study, we used a systems biology approach to identify common metastatic pathways that are jointly supported by both mRNA and protein expression data in two distinct human metastatic OS models.

Results

mRNA expression microarray and N-linked glycoproteomic analyses were performed on two commonly used isogenic pairs of human metastatic OS cell lines, namely HOS/143B and SaOS-2/LM7. Pathway analysis of the differentially regulated genes and glycoproteins separately reve

SUBMITTER: Flores RJ 

PROVIDER: S-EPMC3431263 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature