External drive to inhibitory cells induces alternating episodes of high- and low-amplitude oscillations.

ABSTRACT: Electrical oscillations in neuronal network activity are ubiquitous in the brain and have been associated with cognition and behavior. Intriguingly, the amplitude of ongoing oscillations, such as measured in EEG recordings, fluctuates irregularly, with episodes of high amplitude alternating with episodes of low amplitude. Despite the widespread occurrence of amplitude fluctuations in many frequency bands and brain regions, the mechanisms by which they are generated are poorly understood. Here, we show that irregular transitions between sub-second episodes of high- and low-amplitude oscillations in the alpha/beta frequency band occur in a generic neuronal network model consisting of interconnected inhibitory and excitatory cells that are externally driven by sustained cholinergic input and

SUBMITTER: Avella Gonzalez OJ 

PROVIDER: S-EPMC3431298 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature