Mortality after fluid bolus in children with shock due to sepsis or severe infection: a systematic review and meta-analysis.

ABSTRACT:

Introduction

Sepsis is one of the leading causes of childhood mortality, yet controversy surrounds the current treatment approach. We conducted a systematic review to assess the evidence base for fluid resuscitation in the treatment of children with shock due to sepsis or severe infection.

Methods

We searched 3 databases for randomized trials, quasi-randomized trials, and controlled before-after studies assessing children with septic shock in which at least one group was treated with bolus fluids. The primary outcome was mortality at 48 hours. Assessment of methodological quality followed the GRADE criteria. Relative risks (RRs) and 95% confidence intervals (CI) were calculated and data pooled using fixed-effects method.

Results

13 studies met our inclusion criteria.

SUBMITTER: Ford N 

PROVIDER: S-EPMC3431361 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature