Prevalence, genotype distribution and persistence of human papillomavirus in oral mucosa of women: a six-year follow-up study.

ABSTRACT:

Background

Human papillomavirus (HPV) infections have been linked to a subset of oral and oropharyngeal cancers. However, little is known on the natural history of oral HPV infections. We designed the prospective Finnish HPV Family Study to assess the dynamics of HPV infections in parents and their infants. This study reports HPV genotype distribution and virus persistence in oral mucosa of the mothers.

Materials and methods

Totally, 324 pregnant women were enrolled at the 3(rd) trimester of pregnancy and followed-up for 6 years. Oral scrapings taken with a brush were collected and HPV-genotyping was performed with nested PCR and Multimetrix® test (Progen, Heidelberg, Germany). The predictors of persistent oral HPV species 7/9 infections were analyzed using generalized estim

SUBMITTER: Rautava J 

PROVIDER: S-EPMC3431392 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature