Nonlinear dependencies of biochemical reactions for context-specific signaling dynamics.

ABSTRACT: Mathematical modeling can provide unique insights and predictions about a signaling pathway. Parameter variations allow identification of key reactions that govern signaling features such as the response time that may have a direct impact on the functional outcome. The effect of varying one parameter, however, may depend on values of another. To address the issue, we performed multi-parameter variations of an experimentally validated mathematical model of NF-κB regulatory network, and analyzed the inter-relationships of the parameters in shaping key dynamic features. We find that nonlinear dependencies are ubiquitous among parameters. Such phenomena may underlie the emergence of cell type-specific behaviors from essentially the same molecular network. Our results from a multivariate ensemb

SUBMITTER: Sung MH 

PROVIDER: S-EPMC3431543 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature