A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans.

ABSTRACT:

Background & aims

Epithelial cancers can be initiated by activating mutations in components of the mitogen-activated protein kinase signaling pathway such as v-raf murine sarcoma viral oncogene homolog B1 (BRAF), v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS), or epidermal growth factor receptor (EGFR). Human intestinal serrated polyps are a heterogeneous group of benign lesions, but some progress to colorectal cancer. Tumors that arise from these polyps frequently contain activating mutations in BRAF or KRAS, but little is known about the role of EGFR activation in their development.

Methods

Polyp samples were obtained from adults during screening colonoscopies at Mount Sinai Hospital in New York. We measured levels of EGFR protein and phosphorylation in human

SUBMITTER: Bongers G 

PROVIDER: S-EPMC3431560 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature