Activity-based near-infrared fluorescent probe for LMP7: a chemical proteomics tool for the immunoproteasome in living cells.

ABSTRACT: Probing the unknown: The immunoproteasome, an alternative form of the constitutive proteasome, has been implicated in a number of pathological states such as cancer and autoimmune diseases. In an effort to understand the role of the immunoproteasome in cells, the first immunoproteasome-specific near-infrared fluorescent probe has been developed.

SUBMITTER: Sharma LK 

PROVIDER: S-EPMC3431601 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature