Comparative analysis of diguanylate cyclase and phosphodiesterase genes in Klebsiella pneumoniae.

ABSTRACT:

Background

Klebsiella pneumoniae can be found in environmental habitats as well as in hospital settings where it is commonly associated with nosocomial infections. One of the factors that contribute to virulence is its capacity to form biofilms on diverse biotic and abiotic surfaces. The second messenger Bis-(3'-5')-cyclic dimeric GMP (c-di-GMP) is a ubiquitous signal in bacteria that controls biofilm formation as well as several other cellular processes. The cellular levels of this messenger are controlled by c-di-GMP synthesis and degradation catalyzed by diguanylate cyclase (DGC) and phophodiesterase (PDE) enzymes, respectively. Many bacteria contain multiple copies of these proteins with diverse organizational structure that highlight the complex regulatory mechanisms of this s

SUBMITTER: Cruz DP 

PROVIDER: S-EPMC3431978 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature