Early-onset ventilator-associated pneumonia in adults randomized clinical trial: comparison of 8 versus 15 days of antibiotic treatment.

ABSTRACT:

Purpose

The optimal treatment duration for ventilator-associated pneumonia is based on one study dealing with late-onset of the condition. Shortening the length of antibiotic treatment remains a major prevention factor for the emergence of multiresistant bacteria.

Objective

To demonstrate that 2 different antibiotic treatment durations (8 versus 15 days) are equivalent in terms of clinical cure for early-onset ventilator-associated pneumonia.

Methods

Randomized, prospective, open, multicenter trial carried out from 1998 to 2002.

Measurements

The primary endpoint was the clinical cure rate at day 21. The mortality rate was evaluated on days 21 and 90.

Results

225 patients were included in 13 centers. 191 (84.9%) patients were cured: 92 out of 109 (84.4%)

SUBMITTER: Capellier G 

PROVIDER: S-EPMC3432026 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature