The alteration of lipid metabolism in Burkitt lymphoma identifies a novel marker: adipophilin.

ABSTRACT:

Background

Recent evidence suggests that lipid pathway is altered in many human tumours. In Burkitt lymphoma this is reflected by the presence of lipid droplets which are visible in the cytoplasm of neoplastic cells in cytological preparations. These vacuoles are not identifiable in biopsy section as lipids are "lost" during tissue processing.

Methods and results

In this study we investigated the expression of genes involved in lipid metabolism, at both RNA and protein level in Burkitt lymphoma and in other B-cell aggressive lymphoma cases. Gene expression profile indicated a significant over-expression of the adipophilin gene and marked up-regulation of other genes involved in lipid metabolism in Burkitt lymphoma. These findings were confirmed by immunohistochemistry on a s

SUBMITTER: Ambrosio MR 

PROVIDER: S-EPMC3432109 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature