Ontology highlight
ABSTRACT:
SUBMITTER: Iliev ID
PROVIDER: S-EPMC3432565 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20120606 6086
The intestinal microflora, typically equated with bacteria, influences diseases such as obesity and inflammatory bowel disease. Here, we show that the mammalian gut contains a rich fungal community that interacts with the immune system through the innate immune receptor Dectin-1. Mice lacking Dectin-1 exhibited increased susceptibility to chemically induced colitis, which was the result of altered responses to indigenous fungi. In humans, we identified a polymorphism in the gene for Dectin-1 (CL ...[more]