Genetic analysis of ancestry, admixture and selection in Bolivian and Totonac populations of the New World.

ABSTRACT:

Background

Populations of the Americas were founded by early migrants from Asia, and some have experienced recent genetic admixture. To better characterize the native and non-native ancestry components in populations from the Americas, we analyzed 815,377 autosomal SNPs, mitochondrial hypervariable segments I and II, and 36 Y-chromosome STRs from 24 Mesoamerican Totonacs and 23 South American Bolivians.

Results and conclusions

We analyzed common genomic regions from native Bolivian and Totonac populations to identify 324 highly predictive Native American ancestry informative markers (AIMs). As few as 40-50 of these AIMs perform nearly as well as large panels of random genome-wide SNPs for predicting and estimating Native American ancestry and admixture levels. These AIMs hav

SUBMITTER: Watkins WS 

PROVIDER: S-EPMC3432609 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature