Mouse ooplasm confers context-specific reprogramming capacity.

ABSTRACT: Enucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer, such as germline-associated promoters, as well as unique limitations that include certain repetitive element classes.

SUBMITTER: Chan MM 

PROVIDER: S-EPMC3432711 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature