Unknown

Dataset Information

0

Mouse ooplasm confers context-specific reprogramming capacity.

ABSTRACT: Enucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer, such as germline-associated promoters, as well as unique limitations that include certain repetitive element classes.

SUBMITTER: Chan MM 

PROVIDER: S-EPMC3432711 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Mouse ooplasm confers context-specific reprogramming capacity.

Chan Michelle M MM   Smith Zachary D ZD   Egli Dieter D   Regev Aviv A   Meissner Alexander A  

Nature genetics 20120819 9

Enucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer, such as germline-associated promoters, as well as unique limitations that include certain repetitive element classes. ...[more]

Similar Datasets

Genomics Mouse ooplasm confers context-specific reprogramming capacity
2012-08-10 | E-GEOD-38711 | biostudies-arrayexpress
Methylation profiling Mouse ooplasm confers context-specific reprogramming capacity
2012-08-10 | GSE38711 | GEO
Unknown Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming.
| S-EPMC6632093 | biostudies-literature
Unknown A specific subdomain in phi29 DNA polymerase confers both processivity and strand-displacement capacity.
| S-EPMC1088371 | biostudies-literature
Unknown Histone variant macroH2A confers resistance to nuclear reprogramming.
| S-EPMC3116279 | biostudies-literature
Unknown ERBB4 confers metastatic capacity in Ewing sarcoma.
| S-EPMC3721475 | biostudies-literature
Transcriptomics Asymmetric Reprogramming Capacity of Parental Pronuclei in Mouse Zygote
2014-12-30 | GSE49148 | GEO
Unknown Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming.
| S-EPMC7502540 | biostudies-literature
Unknown The transcriptomic architecture of mouse Sertoli cell clone embryos reveals temporal–spatial-specific reprogramming.
| S-EPMC3607486 | biostudies-literature
Unknown Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders.
| S-EPMC6831688 | biostudies-literature