A general solution for the 2-pyridyl problem.

ABSTRACT: Problem solved: an air-stable 2-pyridyl borane that can effectively couple to a wide range of aryl and heteroaryl halides and pseudohalides has evaded the synthesis community for decades. The discovery that Cu(DEA)(2) powerfully enables palladium-mediated cross-couplings with air-stable boronates 1 has finally provided a general solution to this problem. DEA=diethanolamine, DMF=N,N'-dimethylformamide, Tf=trifluoromethanesulfonyl.

SUBMITTER: Dick GR 

PROVIDER: S-EPMC3433254 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature