Shared paramyxoviral glycoprotein architecture is adapted for diverse attachment strategies.

ABSTRACT: Members within the paramyxovirus subfamily Paramyxovirinae constitute a large number of highly virulent human and animal pathogens. The glycoproteins present on these viruses are responsible for mediating host cell attachment and fusion and are key targets for the design of antiviral entry inhibitors. In the present review, we discuss recent structural studies which have led to a better understanding of the various mechanisms by which different paramyxoviruses use their attachment glycoproteins to hijack specific protein and glycan cell-surface receptors to facilitate viral entry. It is observed that the paramyxovirus attachment glycoprotein consists of a conserved overall structure which includes an N-terminal six-bladed β-propeller domain which is responsible for cell receptor binding. C

SUBMITTER: Bowden TA 

PROVIDER: S-EPMC3433257 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature