Association of CTXN3-SLC12A2 polymorphisms and schizophrenia in a Thai population.

ABSTRACT:

Background

A genome-wide association study (GWAS) combined with brain imaging as a quantitative trait analysis revealed that the SNPs near CTXN3-SLC12A2 region were related to forebrain development and stress response which involved in schizophrenia. In the present study, the SNPs in this region were analyzed for association with schizophrenia in a Thai population.

Methods

A total of 115 schizophrenia and 173 unrelated normal controls with mean age of 37.87 ± 11.8 and 42.81 ± 6.0 years, respectively, were included in this study. Genotyping was performed using polymerase chain reaction and high-resolution melting (HRM) analysis. The difference in genotype distribution between patient and control was assessed by Chi-square test of the SPSS software.

Results

We found a s

SUBMITTER: Panichareon B 

PROVIDER: S-EPMC3433332 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature