From networks of protein interactions to networks of functional dependencies.

ABSTRACT:

Background

As protein-protein interactions connect proteins that participate in either the same or different functions, networks of interacting and functionally annotated proteins can be converted into process graphs of inter-dependent function nodes (each node corresponding to interacting proteins with the same functional annotation). However, as proteins have multiple annotations, the process graph is non-redundant, if only proteins participating directly in a given function are included in the related function node.

Results

Reasoning that topological features (e.g., clusters of highly inter-connected proteins) might help approaching structured and non-redundant understanding of molecular function, an algorithm was developed that prioritizes inclusion of proteins into the

SUBMITTER: Luciani D 

PROVIDER: S-EPMC3434018 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature