Origin of a novel protein-coding gene family with similar signal sequence in Schistosoma japonicum.

ABSTRACT:

Background

Evolution of novel protein-coding genes is the bedrock of adaptive evolution. Recently, we identified six protein-coding genes with similar signal sequence from Schistosoma japonicum egg stage mRNA using signal sequence trap (SST). To find the mechanism underlying the origination of these genes with similar core promoter regions and signal sequence, we adopted an integrated approach utilizing whole genome, transcriptome and proteome database BLAST queries, other bioinformatics tools, and molecular analyses.

Results

Our data, in combination with database analyses showed evidences of expression of these genes both at the mRNA and protein levels exclusively in all developmental stages of S. japonicum. The signal sequence motif was identified in 27 distinct S. japonic

SUBMITTER: Mbanefo EC 

PROVIDER: S-EPMC3434034 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature