Cocktail sedation containing propofol versus conventional sedation for ERCP: a prospective, randomized controlled study.

ABSTRACT:

Background

ERCP practically requires moderate to deep sedation controlled by a combination of benzodiazepine and opiod. Propofol as a sole agent may cause oversedation. A combination (cocktail) of infused propofol, meperidine, and midazolam can reduce the dosage of propofol and we hypothesized that it might decrease the risk of oversedation. We prospectively compare the efficacy, recovery time, patient satisfactory, and side effects between cocktail and conventional sedations in patients undergoing ERCP.

Methods

ERCP patients were randomized into 2 groups; the cocktail group (n = 103) and the controls (n = 102). For induction, a combination of 25 mg of meperidine and 2.5 mg of midazolam were administered in both groups. In the cocktail group, a bolus dose of propofol 1 mg/kg

SUBMITTER: Angsuwatcharakon P 

PROVIDER: S-EPMC3434082 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature