Total synthesis of (±)-sorocenol B employing nanoparticle catalysis.

ABSTRACT: The total synthesis of (±)-sorocenol B has been accomplished featuring key steps including silver nanoparticle (AgNP)-catalyzed Diels-Alder cycloaddition and late-stage Pd(II)-catalyzed oxidative cyclization. The synthetic natural product exhibited low micromolar cytotoxic activity against a number of human cancer cell lines.

SUBMITTER: Cong H 

PROVIDER: S-EPMC3434240 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature