A genotype risk score predicts type 2 diabetes from young adulthood: the CARDIA study.

ABSTRACT:

Aims/hypothesis

Genotype does not change over the life course and may thus facilitate earlier identification of individuals at high risk for type 2 diabetes. We hypothesised that a genotype score predicts incident type 2 diabetes from young adulthood and improves diabetes prediction models based on clinical risk factors alone.

Methods

The Coronary Artery Risk Development in Young Adults (CARDIA) study followed young adults (aged 18-30 years, mean age 25) serially into middle adulthood. We used Cox regression to build nested prediction models for incident type 2 diabetes based on clinical risk factors assessed in young adulthood (age, sex, race, parental history of diabetes, BMI, mean arterial pressure, fasting glucose, HDL-cholesterol and triacylglyercol), without and with a

SUBMITTER: Vassy JL 

PROVIDER: S-EPMC3434294 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature