Effects of the CACNA1C risk allele on neurocognition in patients with schizophrenia and healthy individuals.

ABSTRACT: Recent genetic association studies have identified the A-allele of rs1006737 within CACNA1C as a risk factor for schizophrenia as well as mood disorders. Some evidence suggests that this polymorphism plays a role in cognitive function both in schizophrenia patients and healthy individuals; however, the precise nature of this association remains unclear. Here we investigated the possible association of this polymorphism with a wide range of neurocognitive functions in schizophrenia patients and in healthy subjects. Schizophrenia patients exhibited significantly poorer performance on all the cognitive domains as compared to healthy controls. In patients, A-allele carriers demonstrated significantly worse logical memory performance than the G-allele homozygotes. In controls, no significant as

SUBMITTER: Hori H 

PROVIDER: S-EPMC3434390 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature