Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development.

ABSTRACT: Embryonic development is controlled by a small set of signal transduction pathways, with vastly different phenotypic outcomes depending on the time and place of their recruitment. How the same molecular machinery can elicit such specific and distinct responses, remains one of the outstanding questions in developmental biology. Part of the answer may lie in the high inherent genetic complexity of these signaling cascades, as observed for the Wnt-pathway. The mammalian genome encodes multiple Wnt proteins and receptors, each of which show dynamic and tightly controlled expression patterns in the embryo. Yet how these components interact in the context of the whole organism remains unknown. Here we report the generation of a novel, inducible transgenic mouse model that allows spatiotemporal c

SUBMITTER: van Amerongen R 

PROVIDER: S-EPMC3435145 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature