Endothelial Semaphorin 7A promotes neutrophil migration during hypoxia.

ABSTRACT: Recent studies identified basic biological principles that are shared by the immune and the nervous system. One of these analogies applies to the orchestration of cellular migration where guidance proteins that serve as a stop signal for axonal migration can also serve as a stop signal for the migration of immune-competent cells. The control of leukocyte migration is of key interest during conditions associated with inflammatory tissue changes such as tissue hypoxia or hypoxic inflammation. Semaphorins are members of these axon guidance molecules. Previously unknown, we report here the expression and induction of semaphorin 7A (SEMA7A) on endothelium through hypoxia-inducible factor 1α during hypoxia. This induction of SEMA7A translates into increased transmigration of polymorphonuclear ne

SUBMITTER: Morote-Garcia JC 

PROVIDER: S-EPMC3435204 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature