Spectral decomposition of P50 suppression in schizophrenia during concurrent visual processing.

ABSTRACT: Reduced suppression of the auditory P50 event-related potential has long been associated with schizophrenia, but the mechanisms associated with the generation and suppression of the P50 are not well understood. Recent investigations have used spectral decomposition of the electroencephalograph (EEG) signal to gain additional insight into the ongoing electrophysiological activity that may be reflected by the P50 suppression deficit. The present investigation extended this line of study by examining how both a traditional measure of sensory gating and the ongoing EEG from which it is extracted might be modified by the presence of concurrent visual stimulation - perhaps better characterizing gating deficits as they occur in a real-world, complex sensory environment. The EEG was obtained from

SUBMITTER: Moran ZD 

PROVIDER: S-EPMC3435431 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature