RYR3 gene polymorphisms and cardiovascular disease outcomes in the context of antihypertensive treatment.

ABSTRACT: Nearly one-third of adults in the United States have hypertension, which is associated with increased cardiovascular disease (CVD) morbidity and mortality. The goal of antihypertensive pharmacogenetic research is to enhance understanding of drug response based on the interaction of individual genetic architecture and antihypertensive therapy to improve blood pressure control and ultimately prevent CVD outcomes. In the context of the Genetics of Hypertension Associated Treatment study and using a case-only design, we examined whether single-nucleotide polymorphisms in RYR3 interact with four classes of antihypertensive drugs, particularly the calcium channel blocker amlodipine versus other classes, to modify the risk of coronary heart disease (CHD; fatal CHD and non-fatal myocardial infarct

SUBMITTER: Lynch AI 

PROVIDER: S-EPMC3435442 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature