Collagen gene variants previously associated with anterior cruciate ligament injury risk are also associated with joint laxity.

ABSTRACT:

Background

Genetic association studies demonstrate a relationship between several collagen gene variants and anterior cruciate ligament (ACL) injury, yet the mechanism of these relationships is still unclear. Joint laxity is a heritable trait; increased magnitudes of anterior knee laxity (AKL), genu recurvatum (GR), and general joint laxity (GJL) have been consistently associated with a greater risk of ACL injury. Joint laxity may constitute an important intermediate phenotype for the genetic association with ACL injury that can be measured clinically.

Hypothesis

To determine if genetic variants within the COL1A1, COL5A1, and COL12A1 genes, previously associated with ACL injury, were also associated with greater magnitudes of AKL, GR, and GJL.

Study design

Descriptive

SUBMITTER: Bell RD 

PROVIDER: S-EPMC3435918 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature