Amputation induces stem cell mobilization to sites of injury during planarian regeneration.

ABSTRACT: How adult stem cell populations are recruited for tissue renewal and repair is a fundamental question of biology. Mobilization of stem cells out of their niches followed by correct migration and differentiation at a site of tissue turnover or injury are important requirements for proper tissue maintenance and regeneration. However, we understand little about the mechanisms that control this process, possibly because the best studied vertebrate adult stem cell systems are not readily amenable to in vivo observation. Furthermore, few clear examples of the recruitment of fully potent stem cells, compared with limited progenitors, are known. Here, we show that planarian stem cells directionally migrate to amputation sites during regeneration. We also show that during tissue homeostasis they ar

SUBMITTER: Guedelhoefer OC 

PROVIDER: S-EPMC3436109 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature