Centrosome movements in vivo correlate with specific neurite formation downstream of LIM homeodomain transcription factor activity.

ABSTRACT: Neurons must develop complex structure to form proper connections in the nervous system. The initiation of axons in defined locations on the cell body and their extension to synaptic targets are critical steps in neuronal morphogenesis, yet the mechanisms controlling axon formation in vivo are poorly understood. The centrosome has been implicated in multiple aspects of neuronal morphogenesis; however, its function in axon development is under debate. Conflicting results from studies of centrosome function in axonogenesis suggest that its role is context dependent and underscore the importance of studying centrosome function as neurons develop in their natural environment. Using live imaging of zebrafish Rohon-Beard (RB) sensory neurons in vivo, we discovered a spatiotemporal relationship b

SUBMITTER: Andersen EF 

PROVIDER: S-EPMC3436112 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature