Ontology highlight
ABSTRACT:
SUBMITTER: Mohibi S
PROVIDER: S-EPMC3436190 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20120626 35
Ada3 protein is an essential component of histone acetyl transferase containing coactivator complexes conserved from yeast to human. We show here that germline deletion of Ada3 in mouse is embryonic lethal, and adenovirus-Cre mediated conditional deletion of Ada3 in Ada3(FL/FL) mouse embryonic fibroblasts leads to a severe proliferation defect which was rescued by ectopic expression of human Ada3. A delay in G(1) to S phase of cell cycle was also seen that was due to accumulation of Cdk inhibito ...[more]