Use of quantitative membrane proteomics identifies a novel role of mitochondria in healing injured muscles.

ABSTRACT: Skeletal muscles are proficient at healing from a variety of injuries. Healing occurs in two phases, early and late phase. Early phase involves healing the injured sarcolemma and restricting the spread of damage to the injured myofiber. Late phase of healing occurs a few days postinjury and involves interaction of injured myofibers with regenerative and inflammatory cells. Of the two phases, cellular and molecular processes involved in the early phase of healing are poorly understood. We have implemented an improved sarcolemmal proteomics approach together with in vivo labeling of proteins with modified amino acids in mice to study acute changes in the sarcolemmal proteome in early phase of myofiber injury. We find that a notable early phase response to muscle injury is an increased associ

SUBMITTER: Sharma N 

PROVIDER: S-EPMC3436295 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature