Ready for a world without antibiotics? The Pensieres Antibiotic Resistance Call to Action.

ABSTRACT: Resistance to antibiotics has increased dramatically over the past few years and has now reached a level that places future patients in real danger. Microorganisms such as Escherichia coli and Klebsiella pneumoniae, which are commensals and pathogens for humans and animals, have become increasingly resistant to third-generation cephalosporins. Moreover, in certain countries, they are also resistant to carbapenems and therefore susceptible only to tigecycline and colistin. Resistance is primarily attributed to the production of beta-lactamase genes located on mobile genetic elements, which facilitate their transfer between different species. In some rare cases, Gram-negative rods are resistant to virtually all known antibiotics. The causes are numerous, but the role of the overuse of antibi

SUBMITTER: Carlet J 

PROVIDER: S-EPMC3436635 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature