Association testing of copy number variants in schizophrenia and autism spectrum disorders.

ABSTRACT:

Background

Autism spectrum disorders and schizophrenia have been associated with an overlapping set of copy number variant loci, but the nature and degree of overlap in copy number variants (deletions compared to duplications) between these two disorders remains unclear.

Methods

We systematically evaluated three lines of evidence: (1) the statistical bases for associations of autism spectrum disorders and schizophrenia with a set of the primary CNVs thus far investigated, from previous studies; (2) data from case series studies on the occurrence of these CNVs in autism spectrum disorders, especially among children, and (3) data on the extent to which the CNVs were associated with intellectual disability and developmental, speech, or language delays. We also conducted new ana

SUBMITTER: Crespi BJ 

PROVIDER: S-EPMC3436704 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature