Defining and searching for structural motifs using DeepView/Swiss-PdbViewer.

ABSTRACT:

Background

Today, recognition and classification of sequence motifs and protein folds is a mature field, thanks to the availability of numerous comprehensive and easy to use software packages and web-based services. Recognition of structural motifs, by comparison, is less well developed and much less frequently used, possibly due to a lack of easily accessible and easy to use software.

Results

In this paper, we describe an extension of DeepView/Swiss-PdbViewer through which structural motifs may be defined and searched for in large protein structure databases, and we show that common structural motifs involved in stabilizing protein folds are present in evolutionarily and structurally unrelated proteins, also in deeply buried locations which are not obviously related to prot

SUBMITTER: Johansson MU 

PROVIDER: S-EPMC3436773 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature