Estrogen metabolism and mammographic density in postmenopausal women: a cross-sectional study.

ABSTRACT:

Background

Prospective studies have consistently found that postmenopausal breast cancer risk increases with circulating estrogens; however, findings from studies of estrogens and mammographic density (MD), an intermediate marker of breast cancer risk, have been inconsistent. We investigated the cross-sectional associations of urinary estrogens, and their 2-, 4-, and 16-hydroxylated metabolites with MD.

Methods

Postmenopausal women without breast cancer (n = 194), ages 48 to 82 years, and reporting no current menopausal hormone therapy use were enrolled at a clinic in Western NY in 2005. Urinary estrogens and estrogen metabolites were measured using mass spectrometry. Percent MD and dense area (cm(2)) were measured using computer-assisted analyses of digitized films. Linear

SUBMITTER: Fuhrman BJ 

PROVIDER: S-EPMC3436977 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature